Imwe nzira inoita kuti masero egomarara ahwande kubva kusimba remuviri rekudzivirira zvirwere nekugadzira chidziviriro chepamusoro chinonzi glycocalyx. Muchidzidzo chitsva ichi, vaongorori vakaongorora zvinhu zvechipingamupinyi ichi nekugadziriswa kusati kwamboitika, kuburitsa ruzivo runogona kubatsira kuvandudza ikozvino cellular cancer immunotherapies.
Masero eCancer anowanzo kuumba glycocalyx ine mazinga akakwirira emasero epamusoro mucins, ayo anofungidzirwa kubatsira kudzivirira kenza masero kubva pakurwiswa nemasero ekudzivirira. Nekudaro, kunzwisisa kwemuviri kweichi chipingamupinyi kunoramba kuri kushoma, kunyanya zvine chekuita ne cell cancer immunotherapy, iyo inosanganisira kubvisa masero edziviriro kubva kumurwere, achiagadzirisa kutsvaga nekuparadza kenza, uyezve kuvadzosera kumurwere.
"Takaona kuti shanduko muhukobvu hwekuvharisa hudiki semanomita gumi hunokanganisa basa rekudzivirira kwemasero edu edziviriro kana masero einjiniya," akadaro Sangwu Park, mudzidzi akapedza kudzidza muMatthew Paszek lab paCornell University kuISAB, New York. "Takashandisa ruzivo urwu kugadzira maseru edziviriro anogona kupfuura nemu glycocalyx, uye isu tinovimba nzira iyi inogona kushandiswa kuvandudza yemazuva ano cellular immunotherapy." Biology.
"Lab yedu yauya nezano rakasimba rinodaidzwa kuti scanning angle interference microscopy (SAIM) yekuyera nanosized glycocalyx yemaseru egomarara," akadaro Park. "Iyi nzira yekufungidzira yakatibvumira kuti tinzwisise hukama hwehukama hwekenza-inosanganisirwa mucins neiyo biophysical zvimiro zve glycocalyx."
Vatsvagiri vakagadzira cellular modhi kuti inyatso kudzora kutaura kwesero pamusoro mucins kutevedzera glycocalyx yekenza maseru. Ivo vakabva vabatanidza SAIM nemajini maitiro ekuongorora kuti huwandu hwepamusoro, glycosylation, uye kuyambuka-kubatanidza kwekenza-inosanganisirwa mucins inokanganisa nanoscale barriers ukobvu. Vakaongororawo kuti kukora kweglycocalyx kunokanganisa sei kuramba kwemasero kurwisa nemasero emuviri.
Chidzidzo ichi chinoratidza kuti ukobvu hwekenza cell glycocalyx ndiyo imwe yematanho makuru anotaridza kuti immune cell evasion, uye kuti masero ekudzivirira ekudzivirira anoshanda zvirinani kana glycocalyx iri mutete.
Zvichienderana neruzivo urwu, vaongorori vakagadzira maseru edziviriro ane ma enzymes akakosha pamusoro pavo anovatendera kuti vabatanidze uye vabatane neiyo glycocalyx. Kuedza padanho remaserura kwakaratidza kuti maseru ekudzivirira aya anokwanisa kukunda glycocalyx nhumbi dzekenza maseru.
Vatsvagiri vanobva varonga kuona kana mhedzisiro iyi inogona kudzokororwa mulabhu uye pakupedzisira mumakiriniki miedzo.
Sangwoo Park ichapa chidzidzo ichi (pfupiso) panguva yechirongwa che “Regulatory Glycosylation in the Spotlight” musi weSvondo, Kurume 26, 2-3 pm PT, Seattle Convention Center, room 608. Bata vezvenhau kuti uwane rumwe ruzivo kana kupasa pachena kune musangano.
Nancy D. Lamontagne munyori wesainzi uye mupepeti paCreative Science Writing muChapel Hill, North Carolina.
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Nguva yekutumira: May-22-2023